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a22f5b15a02f5e159f2f62159f2f66159e2f69159e2f70159f2f7615a02f7c15a22f8215a42f8715a72f8c15ab2f9115af2f9615b42f9a15ba2f9e15c12fa115c82fa415d12fa615da2fa815e42faa15ef2fab15b830b915ae305116232f3516040000002d010200040000002d010300030000000000}\par}}}{
\rtlch\fcs1 \af36 \ltrch\fcs0 \f36\insrsid28593 \cell 
\par }\pard \ltrpar\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0\pararsid13309127\yts19 {\rtlch\fcs1 \ab\af36\afs18 \ltrch\fcs0 \b\f36\fs18\lang1036\langfe1033\langnp1036\insrsid28593\charrsid28593 ERNDIM -}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \lang1036\langfe1033\langnp1036\insrsid28593\charrsid28593  }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \b\f36\fs18\lang1036\langfe1033\langnp1036\insrsid28593\charrsid28593 Quantitative Schemes}{\rtlch\fcs1 \ab\af36\afs18 \ltrch\fcs0 
\b\f36\fs18\lang1036\langfe1033\langnp1036\insrsid28593\charrsid28593 
\par Quantitative Organic Acids}{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang1036\langfe1033\langnp1036\insrsid28593\charrsid28593 \cell }\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 
\rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1036\langfe1033\langnp1036\insrsid28593\charrsid28593 \trowd \irow0\irowband0\ltrrow\ts19\trgaph108\trleft-108\trbrdrt
\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth9546\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid13309127\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvmgf\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth3168\clshdrawnil \cellx3060\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrnone \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth6378\clshdrawnil \cellx9438\row \ltrrow}\trowd \irow1\irowband1\lastrow \ltrrow\ts19\trgaph108\trrh1419\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh
\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 \trftsWidth3\trwWidth9546\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid13309127\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 
\clvmrg\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth1\clshdrawnil \cellx3060\clvertalt\clbrdrt\brdrnone \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrnone 
\cltxlrtb\clftsWidth3\clwWidth3319\clshdrawnil \cellx6379\clvertalt\clbrdrt\brdrnone \clbrdrl\brdrnone \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth3059\clshdrawnil \cellx9438\pard\plain \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0\pararsid13309127\yts19 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af36 \ltrch\fcs0 
\f36\lang1036\langfe1033\langnp1036\insrsid28593\charrsid28593 \cell }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang1036\langfe1033\langnp1036\insrsid28593\charrsid8927368 
\par }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang2057\langfe1033\langnp2057\insrsid28593\charrsid2768477 Dr. M. Duran}{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang2057\langfe1033\langnp2057\insrsid28593 
\par }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang2057\langfe1033\langnp2057\insrsid28593\charrsid2768477 {\*\xmlopen\xmlns2{\factoidname PlaceName}}Academic{\*\xmlclose} {\*\xmlopen\xmlns2{\factoidname PlaceName}}Medical{\*\xmlclose} 
{\*\xmlopen\xmlns2{\factoidname PlaceType}}Center{\*\xmlclose} {\*\xmlopen\xmlns2{\factoidname City}}{\*\xmlopen\xmlns2{\factoidname place}}Amsterdam}{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang2057\langfe1033\langnp2057\insrsid28593 {\*\xmlclose}
{\*\xmlclose}
\par }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang2057\langfe1033\langnp2057\insrsid28593\charrsid2768477 Lab. Genetic Metabolic Diseases
\par }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\insrsid28593\charrsid5864160 P.O. Box 22700
\par }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\insrsid28593\charrsid2768477 NL \endash  1100 DE Amsterdam
\par }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang1040\langfe1033\langnp1040\insrsid28593\charrsid16721166 e-mail\~: 
\par m.duran@amc.}{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang1040\langfe1033\langnp1040\insrsid734308\charrsid16721166 uva.}{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang1040\langfe1033\langnp1040\insrsid28593\charrsid16721166 nl}{\rtlch\fcs1 
\af36 \ltrch\fcs0 \f36\lang1046\langfe1033\langnp1046\insrsid28593\charrsid6493626 
\par }{\rtlch\fcs1 \af36 \ltrch\fcs0 \f36\lang1046\langfe1033\langnp1046\insrsid28593 \cell }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang1040\langfe1033\langnp1040\insrsid28593\charrsid16721166 
\par }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang2057\langfe1033\langnp2057\insrsid28593 Dr. C.W. Weykamp
\par {\*\xmlopen\xmlns2{\factoidname PlaceName}}{\*\xmlopen\xmlns2{\factoidname address}}{\*\xmlopen\xmlns2{\factoidname address}}{\*\xmlopen\xmlns2{\factoidname Street}}{\*\xmlopen\xmlns2{\factoidname place}}Queen{\*\xmlclose}{\*\xmlclose} 
{\*\xmlopen\xmlns2{\factoidname address}}{\*\xmlopen\xmlns2{\factoidname PlaceName}}Beatrix{\*\xmlclose}{\*\xmlclose} {\*\xmlopen\xmlns2{\factoidname address}}{\*\xmlopen\xmlns2{\factoidname PlaceName}}Hospital{\*\xmlclose}{\*\xmlclose}{\*\xmlclose}
{\*\xmlclose}{\*\xmlclose}
\par MCA Laboratory
\par }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang2057\langfe1033\langnp2057\insrsid28593\charrsid9771709 {\*\xmlopen\xmlns2{\factoidname address}}{\*\xmlopen\xmlns2{\factoidname address}}{\*\xmlopen\xmlns2{\factoidname Street}}P.O. Box{\*\xmlclose}
{\*\xmlclose} 9005{\*\xmlclose}
\par }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\insrsid28593\charrsid1124388 NL \endash  7100 }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\insrsid28593 GG Winterswijk}{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\insrsid28593\charrsid1124388 
\par }{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang2057\langfe1033\langnp2057\insrsid28593\charrsid1124388 e-mail\~: c.w.}{\rtlch\fcs1 \af36\afs18 \ltrch\fcs0 \f36\fs18\lang2057\langfe1033\langnp2057\insrsid28593 weykamp@skbwinterswijk.nl}{\rtlch\fcs1 
\af36 \ltrch\fcs0 \f36\lang2057\langfe1033\langnp2057\insrsid28593\charrsid1124388 
\par }\pard \ltrpar\ql \fi-252\li252\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin252\pararsid13309127\yts19 {\rtlch\fcs1 \af36 \ltrch\fcs0 \f36\lang1046\langfe1033\langnp1046\insrsid28593 \cell }\pard\plain \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang2057\langfe1033\langnp2057\insrsid28593\charrsid1124388 \trowd \irow1\irowband1\lastrow \ltrrow\ts19\trgaph108\trrh1419\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 
\trbrdrv\brdrs\brdrw10 \trftsWidth3\trwWidth9546\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid13309127\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvmrg\clvertalc\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth1\clshdrawnil \cellx3060\clvertalt\clbrdrt\brdrnone \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrnone 
\cltxlrtb\clftsWidth3\clwWidth3319\clshdrawnil \cellx6379\clvertalt\clbrdrt\brdrnone \clbrdrl\brdrnone \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth3059\clshdrawnil \cellx9438\row }\pard\plain \ltrpar
\s1\ql \li0\ri0\keepn\widctlpar\wrapdefault\faauto\outlinelevel0\adjustright\rin0\lin0\itap0\pararsid28593 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \ab\af0\afs32 \ltrch\fcs0 
\b\fs32\lang2057\langfe1033\langnp2057\insrsid28593 
\par 
\par }\pard \ltrpar\s1\qc \li0\ri0\keepn\widctlpar\wrapdefault\faauto\outlinelevel0\adjustright\rin0\lin0\itap0\pararsid28593 {\rtlch\fcs1 \ab\af0\afs32 \ltrch\fcs0 \b\fs32\lang2057\langfe1033\langnp2057\insrsid28593 Annual Report ERNDIM-EQAS  200}{
\rtlch\fcs1 \ab\af0\afs32 \ltrch\fcs0 \b\fs32\lang2057\langfe1033\langnp2057\insrsid8084533 7}{\rtlch\fcs1 \ab\af0\afs32 \ltrch\fcs0 \b\fs32\lang2057\langfe1033\langnp2057\insrsid28593 
\par }\pard\plain \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
\par 
\par {\listtext\pard\plain\ltrpar \rtlch\fcs1 \ab\ai\af0\afs28 \ltrch\fcs0 \b\i\fs28\lang2057\langfe1033\langnp2057\langfenp1033\insrsid15688909 \hich\af0\dbch\af0\loch\f0 1.\tab}}\pard \ltrpar\ql \fi-705\li705\ri0\widctlpar
\jclisttab\tx705\wrapdefault\faauto\ls1\adjustright\rin0\lin705\itap0 {\rtlch\fcs1 \ab\ai\af0\afs28 \ltrch\fcs0 \b\i\fs28\lang2057\langfe1033\langnp2057\insrsid15688909 Purpose
\par }\pard \ltrpar\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
The purpose of the ERNDIM External Quality Assurance Scheme for Quantitative Organic Acids is the monitoring of the analytical performance of the quantitative assay of organic acids in urine in laboratories involved in the diagnosis and follow-up of patie
nts with inherited metabolic disorders. For detailed information see }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909  HYPERLINK http://www.ERNDIMQA.nl }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid7699555 {\*\datafield 
00d0c9ea79f9bace118c8200aa004ba90b0200000017000000100000007700770077002e00450052004e00440049004d00510041002e006e006c000000e0c9ea79f9bace118c8200aa004ba90b3000000068007400740070003a002f002f007700770077002e00650072006e00640069006d00710061002e006e006c002f00
000000000000000000005626340000000000000000000000000000000000000000000000000000000000000000000080000000000000}}}{\fldrslt {\rtlch\fcs1 \af0 \ltrch\fcs0 \cs15\ul\cf2\lang2057\langfe1033\langnp2057\insrsid15688909 www.ERNDIMQA.nl}}}\sectd 
\linex0\headery709\footery709\colsx709\endnhere\sectdefaultcl\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909  
\par }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid28593 
\par {\listtext\pard\plain\ltrpar \rtlch\fcs1 \ab\ai\af0\afs28 \ltrch\fcs0 \b\i\fs28\lang2057\langfe1033\langnp2057\langfenp1033\insrsid15688909 \hich\af0\dbch\af0\loch\f0 2.\tab}}\pard \ltrpar\ql \fi-705\li705\ri0\widctlpar
\jclisttab\tx705\wrapdefault\faauto\ls1\adjustright\rin0\lin705\itap0 {\rtlch\fcs1 \ab\ai\af0\afs28 \ltrch\fcs0 \b\i\fs28\lang2057\langfe1033\langnp2057\insrsid15688909 Participants
\par }\pard \ltrpar\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid12281526 71}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909  Laboratories from }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid219750 20}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
 countries participated in the Scheme. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15088633 As there are more}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
 labs which take part in the qualitative OA Scheme}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13963486 s}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15088633 , }{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13963486 apparently}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15088633  not all}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid13963486  diagnostic}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15088633  laboratories feel the need for quantitative analysis of organic acids.}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13963486 \line Nevertheless the Scientific Advisory Board  recommends to implement quantitative organic acid assays. These can be most informative in dete
cting subtle increases of significant organic acids such as ethylmalonic acid in SCAD-deficiency and 3-hydroxyisovaleric acid in Biotinidase deficiency.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
\par }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid28593 
\par {\listtext\pard\plain\ltrpar \rtlch\fcs1 \ab\ai\af0\afs28 \ltrch\fcs0 \b\i\fs28\lang2057\langfe1033\langnp2057\langfenp1033\insrsid15688909 \hich\af0\dbch\af0\loch\f0 3.\tab}}\pard \ltrpar\ql \fi-705\li705\ri0\widctlpar
\jclisttab\tx705\wrapdefault\faauto\ls1\adjustright\rin0\lin705\itap0 {\rtlch\fcs1 \ab\ai\af0\afs28 \ltrch\fcs0 \b\i\fs28\lang2057\langfe1033\langnp2057\insrsid15688909 Design
\par }\pard \ltrpar\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
The Scheme has been designed, planned and coordinated by Dr. Cas Weykamp as scheme organise
r and Dr. Ries Duran as scientific advisor, appointed by the ERNDIM Board. The design includes samples and reports which are connected to provide information with a balance between short-term and long term-reports and between detailed and aggregated infor
mation. 
\par 
\par }\pard\plain \ltrpar\s2\ql \li705\ri0\keepn\widctlpar\wrapdefault\faauto\outlinelevel1\adjustright\rin0\lin705\itap0 \rtlch\fcs1 \ab\ai\af0\afs24\alang1025 \ltrch\fcs0 \b\i\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0 
\ltrch\fcs0 \lang2057\langfe1033\langnp2057\insrsid15688909 Samples
\par }\pard\plain \ltrpar\s16\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang2057\langfe1033\langnp2057\insrsid15688909 The scheme of the year 200}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\insrsid12281526 7}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\insrsid15688909 
 consisted of 8 lyophilised samples, all prepared from the same basic human urine but with various amounts of added analyte. The samples were identical two by two: the pairs, along with the added amounts of analyte and their source are in the table below.
}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\insrsid1002624  The type and level of the analytes were discussed in the Scientific Advisory Board and agreed by the Trust Board.}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang2057\langfe1033\langnp2057\insrsid13963486  As before, the concentrations varied between the physiological range and the typical pathological 
range. The latter may be quite high, e.g. in methylmalonic aciduria and ketosis. One drawback of this system is the relative weight of the sample with the highest concentration with respect to the linearity and recovery calculations. These aspects will ha
ve to be reconsidered.}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\insrsid15688909 
\par 
\par Pairs, added amounts (in micromol/L) of organic acids and their source
\par \ltrrow}\trowd \irow0\irowband0\ltrrow\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcfpat1\clcbpat8\clshdng1500\cltxlrtb\clftsWidth3\clwWidth2411\clcbpatraw8\clcfpatraw1\clshdngraw1500 \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcfpat1\clcbpat8\clshdng1500\cltxlrtb\clftsWidth3\clwWidth1843\clcbpatraw8\clcfpatraw1\clshdngraw1500 \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcfpat1\clcbpat8\clshdng1500\cltxlrtb\clftsWidth3\clwWidth1572\clcbpatraw8\clcfpatraw1\clshdngraw1500 \cellx5400\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcfpat1\clcbpat8\clshdng1500\cltxlrtb\clftsWidth3\clwWidth1530\clcbpatraw8\clcfpatraw1\clshdngraw1500 \cellx6930\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcfpat1\clcbpat8\clshdng1500\cltxlrtb\clftsWidth3\clwWidth1620\clcbpatraw8\clcfpatraw1\clshdngraw1500 \cellx8550\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcfpat1\clcbpat8\clshdng1500\cltxlrtb\clftsWidth3\clwWidth1530\clcbpatraw8\clcfpatraw1\clshdngraw1500 \cellx10080\pard \ltrpar\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\lang2057\langfe1033\langnp2057\insrsid15688909 Analyte\cell Source\cell Added to
\par Pair 1}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid16064141 25}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid15688909 -1}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\lang2057\langfe1033\langnp2057\insrsid16064141 30}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid15688909 \cell Added to
\par Pair 1}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid219750 2}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid16064141 8}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\lang2057\langfe1033\langnp2057\insrsid15688909 -1}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid16064141 3}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid10687746 2}{\rtlch\fcs1 \ab\af0 
\ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid15688909 \cell Added to
\par Pair 1}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid16064141 27}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid15688909 -1}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\lang2057\langfe1033\langnp2057\insrsid219750 2}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid16064141 9}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid15688909 \cell Added to
\par Pair 1}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid16064141 26}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid10687746 -1}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\lang2057\langfe1033\langnp2057\insrsid16064141 31}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1033\langnp2057\insrsid15688909  \cell }\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 
\rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\insrsid15688909 \trowd \irow0\irowband0\ltrrow\ts11\trgaph70\trleft-426\trbrdrt
\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcfpat1\clcbpat8\clshdng1500\cltxlrtb\clftsWidth3\clwWidth2411\clcbpatraw8\clcfpatraw1\clshdngraw1500 \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcfpat1\clcbpat8\clshdng1500\cltxlrtb\clftsWidth3\clwWidth1843\clcbpatraw8\clcfpatraw1\clshdngraw1500 \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcfpat1\clcbpat8\clshdng1500\cltxlrtb\clftsWidth3\clwWidth1572\clcbpatraw8\clcfpatraw1\clshdngraw1500 \cellx5400\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcfpat1\clcbpat8\clshdng1500\cltxlrtb\clftsWidth3\clwWidth1530\clcbpatraw8\clcfpatraw1\clshdngraw1500 \cellx6930\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcfpat1\clcbpat8\clshdng1500\cltxlrtb\clftsWidth3\clwWidth1620\clcbpatraw8\clcfpatraw1\clshdngraw1500 \cellx8550\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcfpat1\clcbpat8\clshdng1500\cltxlrtb\clftsWidth3\clwWidth1530\clcbpatraw8\clcfpatraw1\clshdngraw1500 \cellx10080\row \ltrrow}\trowd \irow1\irowband1\ltrrow\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 
\trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 \trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Hexanoylglycine\cell }\pard\plain \ltrpar
\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 
\fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 VU A\rquote dam\cell }\pard \ltrpar\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 
\fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 
\fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 73\cell 44\cell 22\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {
\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow1\irowband1\ltrrow\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 
\trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 \trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828
\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 
\af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 3Methylglutarate\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0\pararsid9661209 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 Sigma M1512\cell }\pard \ltrpar
\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 145\cell 
87\cell 43\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow2\irowband2\ltrrow
\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Glutarate\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 Sigma G4126\cell }\pard \ltrpar
\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 90\cell 45
\cell 301\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow3\irowband3\ltrrow
\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Fumaric Acid\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 Sigma F2752\cell }\pard \ltrpar
\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 56\cell 28
\cell 185\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow4\irowband4\ltrrow
\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Suberate\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 Sigma S 5200\cell }\pard \ltrpar
\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 24\cell 49
\cell 815\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow5\irowband5\ltrrow
\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 3OH Bytyrate\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0\pararsid9661209 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 Sigma H3145\cell }\pard \ltrpar
\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 151\cell 
302\cell 5016\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow6\irowband6\ltrrow
\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 3OH Propionate\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 Brunet\cell }\pard \ltrpar
\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 51\cell 
515\cell 103\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow7\irowband7\ltrrow
\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Methylmalonate\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 Sigma M5,405.8\cell }\pard \ltrpar
\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 500\cell 
5013\cell 1004\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow8\irowband8\ltrrow
\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Ethylmalonate\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Sigma E8758}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \cell 
}\pard \ltrpar\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 29\cell 
294\cell 59\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow9\irowband9\ltrrow
\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Keto Glutaric acid\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 Sigma K2000\cell }\pard \ltrpar
\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 122\cell 
1223\cell 245\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 
\trowd \irow10\irowband10\ltrrow\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 4OH-Butyric acid\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 Sigma H3635\cell }\pard \ltrpar
\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 41\cell 
407\cell 82\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow11\irowband11\ltrrow
\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Tiglylglycine\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0\pararsid9661209 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 VU A\rquote dam\cell }\pard \ltrpar
\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 267\cell 
107\cell 53\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow12\irowband12\ltrrow
\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 3-OH-Isovalerate\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0\pararsid16392558 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 Brunet\cell }\pard \ltrpar
\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0\pararsid16392558 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 421\cell 
168\cell 84\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow13\irowband13\ltrrow
\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Glycolate\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0\pararsid16392558 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Sigma G8284\cell }\pard \ltrpar\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0\pararsid16392558 {
\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 
\fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 495\cell 198\cell 99\cell }\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow14\irowband14\ltrrow\ts11\trgaph70\trleft-426
\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 D-alpha-OH-glutaric acid\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0\pararsid16392558 \rtlch\fcs1 \af0\afs24\alang1025 
\ltrch\fcs0 \fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Sigma H8378\cell }\pard \ltrpar
\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0\pararsid16392558 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 473\cell 
189\cell 95\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \trowd \irow15\irowband15\ltrrow
\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 N-acetylaspartic acid\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Sigma A5625}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 \cell 
}\pard \ltrpar\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 395\cell 
790\cell 13128\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1033\langnp2057\insrsid8927368\charrsid16064141 
\trowd \irow16\irowband16\ltrrow\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 \clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row \ltrrow}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 D,L-Glyceric acid\cell }\pard\plain \ltrpar\s16\ql \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 Sigma G7274\cell }\pard \ltrpar\s16\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 
\af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 0\cell }\pard\plain \ltrpar\qc \li0\ri0\widctlpar\intbl\wrapdefault\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 
\fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 492\cell 246\cell 1639\cell }\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid8927368\charrsid16064141 \trowd \irow17\irowband17\lastrow \ltrrow\ts11\trgaph70\trleft-426\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 \trftsWidth3\trwWidth10506\trftsWidthB3\trftsWidthA3\trpaddl70\trpaddr70\trpaddfl3\trpaddfr3\tblrsid8927368\tblind-356\tblindtype3 
\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth2411\clshdrawnil \cellx1985\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1843\clshdrawnil \cellx3828\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1572\clshdrawnil \cellx5400\clvertalb\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx6930\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1620\clshdrawnil \cellx8550\clvertalb\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1530\clshdrawnil \cellx10080\row }\pard\plain \ltrpar
\s2\ql \li705\ri0\keepn\widctlpar\wrapdefault\faauto\outlinelevel1\adjustright\rin0\lin705\itap0 \rtlch\fcs1 \ab\ai\af0\afs24\alang1025 \ltrch\fcs0 \b\i\fs24\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang2057\langfe1033\langnp2057\insrsid12137559 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\insrsid15688909 Reports
\par }\pard\plain \ltrpar\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 All data-transfer, the introduction of data by the subscribers (methods, results) as well as their request of reports was done via the interactive website }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909  HYPERLINK http://www.erndimqa.nl }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7699555 {\*\datafield 
00d0c9ea79f9bace118c8200aa004ba90b0200000017000000100000007700770077002e00650072006e00640069006d00710061002e006e006c000000e0c9ea79f9bace118c8200aa004ba90b3000000068007400740070003a002f002f007700770077002e00650072006e00640069006d00710061002e006e006c002f00
00000000000000000000003100000000000000000000000000000000000000000000000000000000000000000000000000060100001a}}}{\fldrslt {\rtlch\fcs1 \af0 \ltrch\fcs0 \cs15\ul\cf2\lang2057\langfe1033\langnp2057\insrsid15688909 www.erndimqa.nl}}}\sectd 
\linex0\headery709\footery709\colsx709\endnhere\sectdefaultcl\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 . 
\par 
\par The website supplies short-term and long-term
 reports. Short-term reports are associated with the eight individual specimens, for which a specific deadline has previously been established for each . Two weeks after the respective deadlines participants can request their reports and thus can update t
h
e information on their analytical performance. Although technically not required, a delay time of 14 days has been arbitrarily chosen to enable the scientific advisor to inspect the results and add his comment to the report. In contrast to the rapidly ava
ilable short-term reports the annual long-term report is based on the designed connection between samples \endash 
 as described above - which enables to report a range of analytical parameters (accuracy, precision, linearity, recovery and inter-laboratory dispersion) once an annual cycle has been completed.
\par 
\par Another characteristic of the website is the variety of result presentations which allows laboratories to make an individual choice for detailed and/or aggregated reports. The most detailed report which can be requested from the website is the \'93
Analyte in Detail\'94 which shows results of a specific analyte in a specific sample (136 such Analyte-in-Detail-reports could be consulted in the  200}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid12281526 7}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909  cycle). A more condensed report is the \'93Cycle Review\'94 which summarizes 
the performance of all analytes in a specific sample (8 such Cycle-Review-Reports were available in 200}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid12281526 7}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 ). The highest degree of aggregation is the Annual Report which summarizes the performance of all analytes of all 8 samples. Depending on the informatio
n one wants to obtain one can choose to have a glance at only the annual report (e.g. laboratory managers) or study all 136 detailed reports (person in charge of the workplace, technicians). 
\par {\listtext\pard\plain\ltrpar \rtlch\fcs1 \ab\ai\af0\afs28 \ltrch\fcs0 \b\i\fs28\lang2057\langfe1033\langnp2057\langfenp1033\insrsid15688909 \hich\af0\dbch\af0\loch\f0 4.\tab}}\pard \ltrpar\ql \fi-705\li705\ri0\widctlpar
\jclisttab\tx705\wrapdefault\faauto\ls1\adjustright\rin0\lin705\itap0 {\rtlch\fcs1 \ab\ai\af0\afs28 \ltrch\fcs0 \b\i\fs28\lang2057\langfe1033\langnp2057\insrsid15688909 Discussion of Results in the Annual Report 200}{\rtlch\fcs1 \ab\ai\af0\afs28 
\ltrch\fcs0 \b\i\fs28\lang2057\langfe1033\langnp2057\insrsid12281526 7}{\rtlch\fcs1 \ab\ai\af0\afs28 \ltrch\fcs0 \b\i\fs28\lang2057\langfe1033\langnp2057\insrsid15688909 
\par }\pard \ltrpar\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 Subsequentl
y we present accuracy, recovery, precision, linearity, interlab CV and cross sectional relations. It may be helpful to print your results of the annual report from the Interactive Website before reading the following comments and keep in mind that we only
 discuss the results of all labs in general: it is up to you to inspect and interpret the specific results of your laboratory and - where needed \endash  to investigate the cause of unsatisfactory results and to correct the procedure. 
\par Whenever serious problems are encountered, contact may be made with your National Representative or eventually with the Scientific Advisor.
\par }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
\par }{\rtlch\fcs1 \ab\ai\af0\afs24 \ltrch\fcs0 \b\i\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 4.1 \tab Accuracy}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
\par }\pard \ltrpar\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
A first approach to describe accuracy is to compare the mean outcome in the eight \tab samples in your lab with the mean in all labs. This is shown in the column "Your Lab" and "All labs" under the heading "Accuracy". 
\par 
\par {\listtext\pard\plain\ltrpar \rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\langfenp1033\insrsid15688909 \hich\af0\dbch\af0\loch\f0 4.2\tab}}\pard \ltrpar\ql \fi-360\li360\ri0\widctlpar
\jclisttab\tx360\wrapdefault\faauto\ls4\ilvl1\adjustright\rin0\lin360\itap0 {\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\lang2057\langfe1033\langnp2057\insrsid15688909  \tab }{\rtlch\fcs1 \ab\ai\af0\afs24 \ltrch\fcs0 
\b\i\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 Recovery
\par }\pard \ltrpar\ql \li709\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin709\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
A second approach to describe accuracy is the percentage recovery of added analyte.  In this approach it is 
assumed that the recovery of the weighed quantities is the target value. The correlation between weighed quantities as added to the samples (on the x-axis) and the measured quantities (on the y-axis) have been calculated. The slope of the correlation mult
iplied with 100% is the recovery of the added amounts. The column \'93Recovery\'94 shows your recovery in the respective organic acids in comparison to the median recovery of all laboratories. The median recovery ranges from }{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid12281526 23}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 % 3}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 -OH-}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 propionic acid (we have doubt on the purity of the spiking material used as the recovery was 95% in 2005)}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909  to 1}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 0}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid5506278 9}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 % (}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 2-OH Glutaric acid}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 )}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 . }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13963486 
The recovery of 4-OH-butyric acid was quite low (}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid12281526 5}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13963486 
4%), possibly as a result of lactone formation, either during the production of the samples of during the extraction / derivatisation.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 The overall mean recovery is 8}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid12281526 3}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid5981799 %}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 . Conclusions from aggregated data are generalisations which should render the participants to the QC-programs (and even more the end- users of the data) cautious about utilizing data from 
other labs without asking about proof of reliability. The difficulties we face are certainly a challenge for developing improved methods.
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\insrsid15688909 
\par {\listtext\pard\plain\ltrpar \rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\langfenp1033\insrsid15688909 \hich\af0\dbch\af0\loch\f0 4.2.1\tab}}\pard \ltrpar\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\faauto\ls4\ilvl2\adjustright\rin0\lin720\itap0 {\rtlch\fcs1 \ab\ai\af0\afs24 \ltrch\fcs0 \b\i\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 Precision
\par }\pard \ltrpar\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 Reproducibility is an important parameter for quality in the laboratory}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid1002624 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909  The CV is calculated from th
e pairs of the scheme which can be regarded as duplicates  (Intra Laboratory CV as indicator }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid1002624 o}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 f reproducibility). Since there are only four pairs, the calculated precision can only give an indication about the reproducibility of the individual laboratory. It allows, however, comparison}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid1002624  total group}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909  of the individual performance with that of }{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid1002624 the }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
participants. The results in comparison to the median of all labs is shown in the column \'93Precision\'94 of the Annual Report. Precision ranges from}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid1002624  }{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 2.9}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid1002624  % for }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid3621006 creatinine }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 to a poor }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 3}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid12281526 9.0}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 % for }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid12281526 4}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 -OH-}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid12281526 butyric acid }{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 with an overall intra-lab CV of 2}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid12281526 2.6}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 %. 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid1002624 In general the best precision was observed for the simple dicarboxylic acids such as ethylmalonate and glutarate; lower scores of
 the hydroxyacids may have been the consequence of non-optimal extraction efficacies.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13963486 
 Rigorous standardization of the extraction parameters, i.e. pH of the sample and exact volume of extraction solvent may be a way to improve this aspect.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid1002624 
\par }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid12987804 
\par {\listtext\pard\plain\ltrpar \rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\langfenp1033\insrsid15688909 \hich\af0\dbch\af0\loch\f0 4.2.2\tab}}\pard \ltrpar\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\faauto\ls4\ilvl2\adjustright\rin0\lin720\itap0 {\rtlch\fcs1 \ab\ai\af0\afs24 \ltrch\fcs0 \b\i\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 Linearity
\par }\pard \ltrpar\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
Linearity over the whole relevant analytical range is another important parameter for analytical quality. The regression has been calculated taking the final}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid1002624  measured
}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909  concentration of the addition as independent (x) variable and the measured concentrations
 as the dependent (=y). The regression coefficient r of the individual and the median of all labs are shown in the columns \'93Linearity\'94of the annual report. It can be seen that the coefficients of regression range from 0.9}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13641235 478 }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 for }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid986582 h}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 exanoylglycine}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909  to 0.99}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid3621006 9}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13641235 5}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909  for suberic acid. 

\par }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
\par {\listtext\pard\plain\ltrpar \rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\langfenp1033\insrsid15688909 \hich\af0\dbch\af0\loch\f0 4.2.3\tab}}\pard \ltrpar\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\faauto\ls4\ilvl2\adjustright\rin0\lin720\itap0 {\rtlch\fcs1 \ab\ai\af0\afs24 \ltrch\fcs0 \b\i\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 Interlab CV
\par }\pard \ltrpar\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
For comparison of outcome for one patient in different hospitals and for use of shared reference values it is relevant to have a high degree of harmonization between results of various laboratories
. Part of the scheme design is to monitor this by calculating the Interlaboratory CV. This, along with the number of laboratories who submitted results, is shown in the column \'93Data All labs\'94
 in the Annual report. It can be seen that most laboratories submitted results for methylmalonic acid (}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13641235 71}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid3621006 )}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid986582  wh}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 ereas only 4}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13641235 4}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006  p}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 articipated for }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid986582 t}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 
iglylglycine}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 . The Inter-lab CV ranges from }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 5.}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13641235 1}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid1002624  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 % for}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid2495537  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 creatinine}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909  to }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13641235 758.2}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid986582 %}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006  for }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13641235 Tiglylglycine}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 . 
\par }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
\par {\listtext\pard\plain\ltrpar \rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\langfenp1033\insrsid15688909 \hich\af0\dbch\af0\loch\f0 4.2.4\tab}}\pard \ltrpar\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\faauto\ls4\ilvl2\adjustright\rin0\lin720\itap0 {\rtlch\fcs1 \ab\ai\af0\afs24 \ltrch\fcs0 \b\i\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 Cross Sectional Relations
\par }\pard \ltrpar\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 The various parameters as described above often have
 an interrelation: often more than one parameter directs towards good or bad analytical control. This pattern is not clearly seen in the organic acids scheme. 
\par 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid28593 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \fs28\lang2057\langfe1033\langnp2057\langfenp1033\insrsid15688909 \hich\af0\dbch\af0\loch\f0 5\tab}}\pard\plain \ltrpar\s3\ql \fi-360\li360\ri0\keepn\widctlpar
\jclisttab\tx709\wrapdefault\faauto\ls4\outlinelevel2\adjustright\rin0\lin360\itap0 \rtlch\fcs1 \ab\ai\af0\afs28\alang1025 \ltrch\fcs0 \b\i\fs28\lang2057\langfe1033\cgrid\langnp2057\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15688909 
Conclusions & Summary
\par }\pard\plain \ltrpar\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid5981799 The high in}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
terlab CV  demonstrates clearly the major problem in the analysis of organic acids: lack of standardization.  Precision with a mean CV of 2}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13641235 2.6}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 % is much better indicating that reproducibility within the labs is not too bad. Linearity is also no major problem and recovery is also quite acceptable. }{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909\charrsid15688909 
In this respect it should be noted that steps are being taken to prepare extra samples which may be used as calibrators, given that the weighed additions and the median calculated values are known. More information 
will be distributed through the regular ERNDIM-channels.
\par We invite you to review your data carefully and especially study your recoveries. These may give an indication of deviant calibration. 
\par }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
\par 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \fs28\lang2057\langfe1033\langnp2057\langfenp1033\insrsid15688909 \hich\af0\dbch\af0\loch\f0 6\tab}}\pard\plain \ltrpar\s3\ql \fi-360\li360\ri0\keepn\widctlpar
\jclisttab\tx709\wrapdefault\faauto\ls4\outlinelevel2\adjustright\rin0\lin360\itap0 \rtlch\fcs1 \ab\ai\af0\afs28\alang1025 \ltrch\fcs0 \b\i\fs28\lang2057\langfe1033\cgrid\langnp2057\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15688909 
Preview Scheme 200}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13641235 8}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15688909 
\par }\pard\plain \ltrpar\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0\pararsid13641235 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 The}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid2495537  200}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13641235 8}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid2495537  scheme }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 will}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid2495537  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 be }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13641235 quite }{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid3621006 similar to 200}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid13641235 7.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
\par }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid12987804 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \fs28\lang2057\langfe1033\langnp2057\langfenp1033\insrsid15688909 \hich\af0\dbch\af0\loch\f0 7\tab}}\pard\plain \ltrpar\s3\ql \fi-360\li360\ri0\keepn\widctlpar
\jclisttab\tx709\wrapdefault\faauto\ls4\outlinelevel2\adjustright\rin0\lin360\itap0 \rtlch\fcs1 \ab\ai\af0\afs28\alang1025 \ltrch\fcs0 \b\i\fs28\lang2057\langfe1033\cgrid\langnp2057\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15688909 
Questions, Comments and Suggestions
\par }\pard\plain \ltrpar\ql \li705\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin705\itap0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1043\langfe1033\cgrid\langnp1043\langfenp1033 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 If you have any questions, comments or suggestions, please address to the scientific advisor of the scheme Dr. Ries Duran (}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909  HYPERLINK mailto:m.duran@\'85\'85 }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\insrsid7699555 {\*\datafield 
00d0c9ea79f9bace118c8200aa004ba90b02000000170000000b0000006d002e0064007500720061006e004000262026200000e0c9ea79f9bace118c8200aa004ba90b240000006d00610069006c0074006f003a006d002e0064007500720061006e0040002620262000000000000000000000000000000000000020000000
000000000000000a002d01000004}}}{\fldrslt {\rtlch\fcs1 \af0 \ltrch\fcs0 \cs15\ul\cf2\lang1033\langfe1033\langnp1033\insrsid15688909 m.duran@amc.uva.nl}}}\sectd \linex0\headery709\footery709\colsx709\endnhere\sectdefaultcl\sftnbj {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 ) and/or the scheme organiser Dr. Cas Weykamp (}{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1033\langnp2057\insrsid15688909 
 HYPERLINK mailto:c.w.weykamp@skbwinterswijk.nl }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\insrsid7699555 {\*\datafield 
00d0c9ea79f9bace118c8200aa004ba90b02000000170000001e00000063002e0077002e007700650079006b0061006d007000400073006b006200770069006e007400650072007300770069006a006b002e006e006c000000e0c9ea79f9bace118c8200aa004ba90b4a0000006d00610069006c0074006f003a0063002e00
77002e007700650079006b0061006d007000400073006b006200770069006e007400650072007300770069006a006b002e006e006c0000000000000000000000000000000000000000000000000000000000000000c11500100e}}}{\fldrslt {\rtlch\fcs1 \af0 \ltrch\fcs0 
\cs15\ul\cf2\lang1033\langfe1033\langnp1033\insrsid15688909 c.w.weykamp@skbwinterswijk.nl}}}\sectd \linex0\headery709\footery709\colsx709\endnhere\sectdefaultcl\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang2057\langfe1033\langnp2057\insrsid15688909 ).
\par Alternatively you may approach your local National Representative, a list of which is available from ERNDIM.
\par 
\par }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid14962793 {\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1033\langnp2057\insrsid15688909 
\par }}